Preferred Label : Sequestosome-1 Protein;
MeSH definition : A multidomain protein that is highly conserved among multicellular organisms. It contains
a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and
interacts with many other signaling proteins and enzymes including, atypical PROTEIN
KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8.
It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates,
and to co-ordinate signaling in response to OXIDATIVE STRESS.;
MeSH synonym : Sequestosome 1 Protein; Ubiquitin-Binding Protein p62; Ubiquitin Binding Protein p62; Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda; Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda; EBI3-Associated Protein of 60 KDa; EBI3 Associated Protein of 60 KDa; EBIAP Protein;
Origin ID : D000071456;
UMLS CUI : C4255261;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A multidomain protein that is highly conserved among multicellular organisms. It contains
a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and
interacts with many other signaling proteins and enzymes including, atypical PROTEIN
KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8.
It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates,
and to co-ordinate signaling in response to OXIDATIVE STRESS.
