" /> Src Homology 2 Domain-Containing, Transforming Protein 1 - CISMeF





Preferred Label : Src Homology 2 Domain-Containing, Transforming Protein 1;

MeSH definition : An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.;

MeSH synonym : Src Homology 2 Domain Containing, Transforming Protein 1; ShcA Protein; SHC1 (Src Homology 2 Domain-Containing) Protein; Src Homology 2 Domain-Containing-Transforming Protein C1; Src Homology 2 Domain Containing Transforming Protein C1; SHC (Src Homology 2 Domain-Containing) Transforming Protein 1; SHC1 Protein; SHC-Transforming Protein 1; SHC Transforming Protein 1;

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An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.

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09/05/2025


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