Suppressor of Cytokine Signaling 3 Protein - CISMeF
Suppressor of Cytokine Signaling 3 ProteinMeSH Descriptor
Preferred Label : Suppressor of Cytokine Signaling 3 Protein;
MeSH definition : A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory
region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid
motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits
cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE
RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR.
Its functions include suppression of ERYTHROPOIESIS in the fetal liver.;
MeSH synonym : Suppressor of Cytokine Signaling Protein 3; SOCS3 Protein; Protein, SOCS3;
A suppressor of cytokine signaling protein that consists of an N-terminal kinase-inhibitory
region, a central SH2 DOMAIN, a characteristic C-terminal SOCS box (a 40-amino acid
motif, which functions to recruit E3 UBIQUITIN-PROTEIN LIGASE COMPLEXES). SOCS3 inhibits
cytokine signaling by binding to RECEPTOR PROTEIN-TYROSINE KINASES as well as CYTOKINE
RECEPTOR GP130; ERYTHROPOIETIN RECEPTORS; INSULIN RECEPTOR; and the LEPTIN RECEPTOR.
Its functions include suppression of ERYTHROPOIESIS in the fetal liver.