Autophagy-Related Protein 7

Preferred Label : Autophagy-Related Protein 7;

MeSH definition : An autophagy related protein that is similar to UBIQUITIN-ACTIVATING ENZYME E1. It functions in CYTOPLASM to VACUOLE transport (Cvt) and AUTOPHAGY by activating ATG12 PROTEIN for its conjugation with ATG5 PROTEIN, as well as the conjugation of ATG8 FAMILY PROTEINS with phosphatidylethanolamine for ATG8 association to Cvt vesicles and AUTOPHAGOSOME membranes. It is also required for the nitrogen starvation response in yeast, MITOPHAGY; and autophagic cell death induced by CASPASE 8 inhibition.;

MeSH synonym : Autophagy Related Protein 7; ATG7 Protein; Ubiquitin-Activating Enzyme E1-like Protein; Ubiquitin Activating Enzyme E1 like Protein; Ubiquitin-Like Modifier-Activating Enzyme ATG7; Ubiquitin Like Modifier Activating Enzyme ATG7; ATG12-Activating Enzyme E1 ATG7; ATG12 Activating Enzyme E1 ATG7;

Registry Number MeSH : EC 6.2.1.45;

UNII : EC 6.2.1.45;

Details

Origin ID

D000071193;

UMLS CUI

C4255232;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Ubiquitin-Like Modifier-Activating Enzyme ATG7 [NCIt concept]
- autophagy related 7 [HGNC gene]
Record concept(s)
- Autophagy-Related Protein 7 [MeSH concept]
Related MeSH Supplementary Concept(s)
- ATG7 protein, S cerevisiae [MeSH Supplementary Concept]
- Atg7 protein, drosophila [MeSH Supplementary Concept]
- Atg7 protein, human [MeSH Supplementary Concept]
- Atg7 protein, mouse [MeSH Supplementary Concept]
- Atg7 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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