MeSH definition : A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM
to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or
ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN
LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization
to vesicle membranes.;
MeSH synonym : Autophagy Related Protein 12; ATG12 Protein; Ubiquitin-Like Protein ATG12; ATG12, Ubiquitin-Like Protein; Ubiquitin Like Protein ATG12;
A UBIQUITIN-like modifier protein that functions in AUTOPHAGOSOME formation, CYTOPLASM
to VACUOLE transport, MITOPHAGY, and nucleophagy. Conjugation with ATG5 PROTEIN or
ATG10 is essential for its function. The ATG12-ATG5 conjugate acts as an E3 UBIQUITIN
LIGASE-like enzyme for lipid modification of ATG8 FAMILY PROTEINS and their localization
to vesicle membranes.