Mismatch Repair Endonuclease PMS2

Preferred Label : Mismatch Repair Endonuclease PMS2;

MeSH definition : A MutL protein and component of the DNA MISMATCH REPAIR system. Its ENDONUCLEASE activity introduces SINGLE-STRAND DNA BREAKS which create entry points for EXO1 exonuclease to remove the strand containing the mismatch. It may also function in DNA DAMAGE signaling.;

MeSH synonym : PMS1 Homolog 2, Mismatch Repair Protein; PMS2 Protein; Postmeiotic Segregation Increased-S. cerevisiae-2; Postmeiotic Segregation Increased S. cerevisiae 2; PMS-2 Protein; PMS 2 Protein;

Registry Number MeSH : EC 3.6.1.3;

UNII : EC 3.6.1.3;

Details

Origin ID

D000070976;

UMLS CUI

C4255087;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Mismatch Repair Endonuclease PMS2 [NCIt concept]
- Mismatch repair endonuclease PMS2 [LOINC component]
- Pms1 homolog 2, mismatch repair system component [OMIM gene]
Record concept(s)
- Mismatch Repair Endonuclease PMS2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- PMS2 protein, human [MeSH Supplementary Concept]
- PMS2 protein, rat [MeSH Supplementary Concept]
- Pms2 protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Mismatch repair endonuclease PMS2 [LOINC component]

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