MeSH definition : Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding
region and LEUCINE-rich repeats. Their general structure consists of any of a variety
of effector domains at their N-termini such as a caspase recruitment domain (CARD),
a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich
repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE
of animals and plants. Members of the NLR protein family include the NOD SIGNALING
ADAPTOR PROTEINS.;
Intracellular signaling proteins that are defined by the presence of a NUCLEOTIDE-binding
region and LEUCINE-rich repeats. Their general structure consists of any of a variety
of effector domains at their N-termini such as a caspase recruitment domain (CARD),
a central nucleotide-binding domain, and a variable number of C-terminal leucine-rich
repeats. They are important for pathogen recognition in the INNATE IMMUNE RESPONSE
of animals and plants. Members of the NLR protein family include the NOD SIGNALING
ADAPTOR PROTEINS.
Allowable qualifiers