Preferred Label : Alarmins;
MeSH definition : A structurally diverse group of endogenous molecules that includes the HMGB1 PROTEIN;
S100 PROTEINS; HSP60, Hsp70, Cathelicidin, IL-33, and DEFENSINS. They are constitutively
available, released upon tissue damage, and activate the immune system. Uncontrolled
and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS,
and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.; A structurally diverse group of endogenous molecules that are multifunctional, having
physiological functions inside the cell, but when released from dying cells or from
cells under stress or certain immune cells, they function to activate INNATE IMMUNITY.
Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS,
and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.;
MeSH synonym : Alarmin; Alarmin Proteins; Damage-Associated Molecular Pattern Molecules; Damage Associated Molecular Pattern Molecules; Danger-Associated Molecular Pattern Molecules; Danger Associated Molecular Pattern Molecules;
CISMeF synonym : Proteins, Alarmin;
Wikipedia link : https://en.wikipedia.org/wiki/Alarmins;
Origin ID : D000067531;
UMLS CUI : C3891560;
Allowable qualifiers
- Currated CISMeF NLP mapping
- Record concept(s)
- Semantic type(s)
- Substance(s)
- UMLS correspondences (same concept)
A structurally diverse group of endogenous molecules that includes the HMGB1 PROTEIN;
S100 PROTEINS; HSP60, Hsp70, Cathelicidin, IL-33, and DEFENSINS. They are constitutively
available, released upon tissue damage, and activate the immune system. Uncontrolled
and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS,
and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
A structurally diverse group of endogenous molecules that are multifunctional, having
physiological functions inside the cell, but when released from dying cells or from
cells under stress or certain immune cells, they function to activate INNATE IMMUNITY.
Uncontrolled and excessive release of alarmins may contribute to INFLAMMATION; CARCINOGENESIS,
and NEOPLASM METASTASIS. Alarmins are also critical for heart and nerve tissue homeostasis.
