Leukemia, acute lymphoblastic

Preferred Label : Leukemia, acute lymphoblastic;

Symbol : ALL;

CISMeF acronym : ALL;

Type : Phenotype or locus, molecular basis unknown;

Included titles and symbols : Leukemia, acute lymphoblastic, susceptibility to, 1; All1; Leukemia, acute lymphocytic, susceptibility to, 1; Leukemia, t-cell acute lymphoblastic, susceptibility to; Leukemia, b-cell acute lymphoblastic, susceptibility to; Leukemia, acute lymphoblastic, b-hyperdiploid, susceptibility to;

Description : Acute lymphoblastic leukemia (ALL), also known as acute lymphocytic leukemia, is a subtype of acute leukemia, a cancer of the white blood cells. Somatically acquired mutations in several genes have been identified in ALL lymphoblasts, cells in the early stages of differentiation. Germline variation in certain genes may also predispose to susceptibility to ALL (Trevino et al., 2009). - Genetic Heterogeneity of Acute Lymphoblastic Leukemia A susceptibility locus for acute lymphoblastic leukemia (ALL1) has been mapped to chromosome 10q21. See also ALL2 (613067), which has been mapped to chromosome 7p12.2; and ALL3 (615545), which is caused by mutation in the PAX5 gene (167414) on chromosome 9p.;

Prefixed ID : %613065;

Details

Origin ID

613065;

UMLS CUI

C1961102;

Automatic exact mappings (from CISMeF team)
- All [HPO term]
- All [NCIt concept]
- BCR activator of RhoGEF and GTPase [ORDO Gene]
- BCR activator of RhoGEF and GTPase [HGNC gene]
- BCR wt Allele [NCIt concept]
- Breakpoint Cluster Region Protein [NCIt concept]
- Does Not Interfere [NCIt concept]
- Easy [NCIt concept]
- Histone-Lysine N-Methyltransferase 2A [NCIt concept]
- KMT2A wt Allele [NCIt concept]
- Lymphoid leukaemia, not elsewhere classified [ICD-11 Subcategory]
- NCI CTEP SDC Acute Lymphoblastic Leukemia Sub-Category Terminology [NCIt concept]
- Not at All [NCIt concept]
- Precursor B-cell acute lymphoblastic leukemia [ORDO Disease]
- Precursor T-cell acute lymphoblastic leukemia [ORDO Disease]
- Severity of Symptom Score 0 [NCIt concept]
- Unable to Do [NCIt concept]
- Universal restriction modifier (core metadata concept) [SNOMED CT concept]
- acute lymphocytic leukemia [MedlinePlus Topic]
- all [Radlex concept]
- anterolateral ligament of knee [UBERON concept]
- lysine methyltransferase 2A [ORDO Gene]
- precursor cell lymphoblastic Leukemia-Lymphoma [MeSH Descriptor]
- precursor cell lymphoblastic Leukemia-Lymphoma [MeSH concept]
Currated CISMeF NLP mapping
- Acute Lymphoblastic Leukemia [NCIt concept]
- Acute lymphoblastic leukaemia [ICD-10 Sub-category (who)]
- Acute lymphoblastic leukaemia [MedDRA LLT]
- Acute lymphoblastic leukemia [HPO term]
- Acute lymphoblastic leukemia [ORDO Disease]
- Acute lymphoblastic leukemia [MedDRA LLT]
- Acute lymphoblastic leukemia [ALL] [ICD-10 Sub-category]
- Acute lymphocytic leukaemia [MedDRA Preferred Term]
- Acute lymphocytic leukemia [PASCAL descriptor]
- Acute lymphoid leukemia, disease (disorder) [SNOMED CT concept]
- Leukaemia lymphoblastic acute [MedDRA LLT]
- Leukemia lymphoblastic acute [MedDRA LLT]
- Leukemia, lymphoblastic, acute [TUV Concept]
- Leukemia, lymphoblastic, acute [TUV Term]
- Lymphoblastic leukaemia NOS [MedDRA LLT]
- Lymphoblastic leukemia NOS [MedDRA LLT]
- Precursor cell lymphoblastic leukemia (morphologic abnormality) [SNOMED CT concept]
- Precursor cell lymphoblastic leukemia, NOS [ICD-O code]
- acute lymphoblastic leukemia [Disease (Nov.)]
- acute lymphoblastic leukemia [DO Concept]
DO Cross reference
- acute lymphoblastic leukemia [DO Concept]
Genes related to phenotype
- Bcl2-associated X protein [OMIM gene]
- Fms-related tyrosine kinase 3 [OMIM gene]
- Guanine nucleotide-binding protein, beta-1 [OMIM gene]
- Nibrin [OMIM gene]
- Nucleoporin, 214-kd [OMIM gene]
- T-cell acute lymphocytic leukemia 1 [OMIM gene]
- T-cell acute lymphocytic leukemia 2 [OMIM gene]
HPO term(s)
- Acute lymphoblastic leukemia [HPO term]
- Polygenic inheritance [HPO term]
- Somatic mutation [HPO term]
ORDO concept(s)
- Acute lymphoblastic leukemia [ORDO Disease]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Precursor cell lymphoblastic leukemia (morphologic abnormality) [SNOMED CT concept]
- Precursor cell lymphoblastic leukemia, NOS [ICD-O code]
- precursor cell lymphoblastic Leukemia-Lymphoma [MeSH Descriptor]
- precursor cell lymphoblastic Leukemia-Lymphoma [MeSH concept]

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