Preferred Label : Monoamine oxidase a;
Obsolete resource : true;
Alternative titles and symbols : Maoa; Amine oxidase (flavin-containing) aantisocial behavior following childhood maltreatment,
susceptibilityto;
Description : Two monoamine oxidase (EC 1.4.3.4) isoenzymes, MAOA and MAOB (309860), are closely
linked in opposite orientation on the X chromosome and are expressed in the outer
mitochondrial membrane. MAOA and MAOB oxidize neurotransmitters and dietary amines,
the regulation of which is important in maintaining normal mental states. MAOA prefers
serotonin, norepinephrine, and dopamine as substrates, whereas MAOB prefers phenylethylamine.
Low levels of MAO activity and mutations in the MAOA gene have been associated with
violent, criminal, or impulsive behavior (Chen et al., 2004).;
Inheritance : X-linked (xp11.4-p11.23);
Origin ID : 309850;
UMLS CUI : C1417001;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- False automatic mappings
- NCIt concept(s)
- ORDO concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
