Preferred Label : Pancreatic cancer;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Pancreatic acinar carcinoma; Pancreatic carcinoma;
Description : Pancreatic cancer shows among the highest mortality rates of any cancer, with a 5-year
relative survival rate of less than 5%. By the time of initial diagnosis, metastatic
disease is commonly present. Established risk factors include a family history of
pancreatic cancer, a medical history of diabetes type 2, and cigarette smoking (summary
by Amundadottir et al., 2009). - Genetic Heterogeneity of Pancreatic Cancer Somatic
mutations in pancreatic cancer occur in the KRAS (190070),;
Inheritance : Somatic mutation; Multifactorial; Autosomal dominant;
Molecular basis : Susceptibility conferred by somatic mutation in Kirsten rat sarcoma-2 viral (v-Ki-ras2)
oncogene homolog gene (KRAS, 190070.0005); Susceptibility conferred by somatic mutation in the tumor protein 53 gene (TP53, 191170.0027); Susceptibility conferred by somatic mutation in the serine/threonine protein kinase
11 gene (STK11, 602216.0015); Susceptibility conferred by somatic mutation in the mothers against decapentaplegic,
Drosophila, homolog of, 4 gene (MADH4, 600993.0001);
Neoplasia : Pancreatic ductal adenocarcinoma;
Prefixed ID : #260350;
Origin ID : 260350;
UMLS CUI : C0235974;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- Genes related to phenotype
- HPO term(s)
- ORDO concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
