Ovarian cancer

Preferred Label : Ovarian cancer;

Type : Phenotype, molecular basis known;

Included titles and symbols : Ovarian cancer, epithelial;

Description : Ovarian cancer, the leading cause of death from gynecologic malignancy, is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases (Chi et al., 2001). These typical features relate to the biology of the disease, which is a principal determinant of outcome (Auersperg et al., 2001). Epithelial ovarian cancer is the most common form and encompasses 5 major histologic subtypes: papillary serous, endometrioid, mucinous, clear cell, and transitional cell. Epithelial ovarian cancer arises as a result of genetic alterations sustained by the ovarian surface epithelium (Stany et al., 2008; Soslow, 2008).;

Inheritance : Somatic mutation;

Neoplasia : Serous ovarian cystadenocarcinoma; Ovarian cancer; Ovarian papillary adenocarcinoma; Dysgerminoma; Breast cancer;

Laboratory abnormalities : Frequent loss of heterozygosity at 6q24-q27;

Prefixed ID : #167000;

Détails

Origin ID

167000;

UMLS CUI

C1140680;

Automatic exact mappings (from CISMeF team)
- Carcinoma, Ovarian Epithelial [MeSH Descriptor]
- Carcinoma, Ovarian Epithelial [MeSH concept]
- Malignant epithelial tumor of ovary [ORDO Disease]
- Ovarian epithelial cancer [MedDRA Preferred Term]
- Rare benign ovarian tumor [ORDO Disease]
Currated CISMeF NLP mapping
- Cancer of ovary [MedDRA LLT]
- Malignant Ovarian Neoplasm [NCIt concept]
- Malignant neoplasm of ovary [ICD-10 category]
- Malignant neoplasm of ovary [ICD-9 code]
- Malignant neoplasm of ovary [ICD-10 category (who)]
- Malignant neoplasm of ovary [MedDRA LLT]
- Malignant neoplasms of ovary [ICD-11 Category]
- Malignant tumor of ovary (disorder) [SNOMED CT concept]
- OVARIAN CARCINOMA [WHO-ART Preferred Term]
- Ovarian Carcinoma [NCIt concept]
- Ovarian cancer [MedDRA Preferred Term]
- Ovarian cancer [ORDO Disease]
- Ovarian cancer NOS [MedDRA LLT]
- Ovarian carcinoma [HPO term]
- Ovarian neoplasm [HPO term]
- Ovary cancer [PASCAL descriptor]
- Primary malignant neoplasm of ovary (disorder) [SNOMED CT concept]
- malignant neoplasm of ovary [SNOMED Notion]
- ovarian cancer [MedlinePlus Topic]
- ovarian cancer [Radlex concept]
- ovarian cancer [DO Concept]
- ovarian carcinoma [TUV Concept]
- ovarian carcinoma [TUV Term]
- ovarian neoplasms [MeSH Descriptor]
- ovary cancer [Disease (Nov.)]
- ovary cancer [MeSH concept]
DO Cross reference
- ovarian cancer [DO Concept]
Genes related to phenotype
- Akt serine/threonine kinase 1 [OMIM gene]
- Cadherin 1 [OMIM gene]
- Catenin, beta-1 [OMIM gene]
- Erb-b2 receptor tyrosine kinase 2 [OMIM gene]
- Opioid-binding protein/cell adhesion molecule-like [OMIM gene]
- Parkin rbr e3 ubiquitin protein ligase [OMIM gene]
- Phosphatidylinositol 3-kinase, catalytic, alpha [OMIM gene]
HPO term(s)
- Autosomal dominant inheritance [HPO term]
- Breast carcinoma [HPO term]
- Dysgerminoma [HPO term]
- Ovarian papillary adenocarcinoma [HPO term]
- Somatic mutation [HPO term]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
UMLS correspondences (same concept)
- Cancer of ovary [MedDRA LLT]
- Malignant Ovarian Neoplasm [NCIt concept]
- Malignant neoplasm of ovary [ICD-10 category (who)]
- Malignant neoplasm of ovary [ICD-9 code]
- Malignant neoplasm of ovary [MedDRA LLT]
- Malignant neoplasm of ovary [ICD-10 category]
- Malignant tumor of ovary (disorder) [SNOMED CT concept]
- Ovarian cancer [MedDRA Preferred Term]
- Ovarian cancer [ORDO Disease]
- Ovarian cancer NOS [MedDRA LLT]
- Ovary cancer [PASCAL descriptor]
- malignant neoplasm of ovary [SNOMED Notion]
- ovarian cancer [MedlinePlus Topic]
- ovary cancer [MeSH concept]
- ovary cancer [Disease (Nov.)]
Validated automatic mappings to BTNT
- ovary carcinoma [Disease (Nov.)]

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