Hypertension, essential

Preferred Label : Hypertension, essential;

CISMeF acronym : EHT;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : EHT;

Description : The Pickering school held that blood pressure has a continuous distribution, that multiple genes and multiple environmental factors determine the level of one's blood pressure just as the determination of stature and intelligence is multifactorial, and that 'essential hypertension' is merely the upper end of the distribution (Pickering, 1978). In this view the person with essential hypertension is one who happens to inherit an aggregate of genes determining hypertension (and also is exposed to exogenous factors that favor hypertension). The Platt school took the view that essential hypertension is a simple mendelian dominant trait (Platt, 1963). McDonough et al. (1964) defended the monogenic idea. See McKusick (1960) and Kurtz and Spence (1993) for reviews. Swales (1985) reviewed the Platt-Pickering controversy as an 'episode in recent medical history.' The Pickering point of view appears to be more consistent with the observations.;

Inheritance : Multifactorial;

Prefixed ID : #145500;

Détails

Origin ID

145500;

UMLS CUI

C0085580;

Automatic exact mappings (from CISMeF team)
- CBFA2T2 wt Allele [NCIt concept]
- Essential Hypertension [MeSH concept]
Currated CISMeF NLP mapping
- Essential (primary) hypertension [ICD-10 category]
- Essential (primary) hypertension [ICD-10 category (who)]
- Essential Hypertension [MeSH Descriptor]
- Essential Hypertension [NCIt concept]
- Essential hypertension [ICD-11 Category]
- Essential hypertension [ICD-9 code]
- Essential hypertension [MedDRA Preferred Term]
- Essential hypertension [ORDO Disease]
- Essential hypertension (disorder) [SNOMED CT concept]
- Hypertension [HPO term]
- Unspecified essential hypertension [ICD-9 code]
- essential hypertension [DO Concept]
- essential hypertension [Disease (Nov.)]
- essential hypertension [Artificial nutrition thesaurus concept]
- essential hypertension, nos [SNOMED Notion]
- high blood pressure [MedlinePlus Topic]
DO Cross reference
- essential hypertension [DO Concept]
Genes related to phenotype
- Adducin 1 [OMIM gene]
- Angiotensin II receptor, type 1 [OMIM gene]
- Cytochrome p450, subfamily iiia, polypeptide 5 [OMIM gene]
- Endothelin-converting enzyme 1 [OMIM gene]
- Guanine nucleotide-binding protein, beta-3 [OMIM gene]
- Prostaglandin i2 synthase [OMIM gene]
HPO term(s)
- Elevated diastolic blood pressure [HPO term]
- Elevated mean arterial pressure [HPO term]
- Elevated systolic blood pressure [HPO term]
- Multifactorial inheritance [HPO term]
Semantic type(s)
- Disease or Syndrome [UMLS semantic type]
UMLS correspondences (same concept)
- Essential (primary) hypertension [ICD-10 category (who)]
- Essential (primary) hypertension [ICD-10 category]
- Essential Hypertension [NCIt concept]
- Essential Hypertension [MeSH Descriptor]
- Essential hypertension [MedDRA Preferred Term]
- Essential hypertension [ORDO Disease]
- Essential hypertension [ICD-9 code]
- Essential hypertension [ICD-11 Category]
- Essential hypertension (disorder) [SNOMED CT concept]
- Essential hypertension, unspecified [MedDRA LLT]
- Primary hypertension [MedDRA LLT]
- Unspecified essential hypertension [ICD-9 code]
- Unspecified essential hypertension [MedDRA LLT]
- essential hypertension [DO Concept]
- essential hypertension [Disease (Nov.)]
- essential hypertension, nos [SNOMED Notion]

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