Preferred Label : Guillain-barre syndrome, familial;
Symbol : GBS;
CISMeF acronym : GBSF; CIDP; GBS;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : Polyneuropathy, inflammatory demyelinating, acute; AIDP;
Included titles and symbols : Polyneuropathy, inflammatory demyelinating, chronic; CIDP;
Description : Guillain-Barre syndrome (GBS) is an acute inflammatory demyelinating polyneuropathy
characterized most commonly by symmetric limb weakness and loss of tendon reflexes.
It is a putative autoimmune disorder presenting after an infectious illness, most
commonly Campylobacter jejuni, a gram-negative bacterium that causes acute enteritis
(Yuki and Tsujino, 1995; Koga et al., 2005). Approximately 1 in 1,000 individuals
develops GBS after C. jejuni infection (Nachamkin, 2001). Although rare familial cases
have been reported, GBS is considered to be a complex multifactorial disorder with
both genetic and environmental factors rather than a disorder following simple mendelian
inheritance (Geleijns et al., 2004).;
Inheritance : ? Autosomal dominant form;
Prefixed ID : #139393;
Origin ID : 139393;
UMLS CUI : C4083008;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- False automatic mappings
- Genes related to phenotype
- HPO term(s)
- Matching ORDO disease(s)
- ORDO concept(s)
- Semantic type(s)
- Validated automatic mappings to BTNT
- Validated automatic mappings to NTBT
