" /> Fibromatosis, gingival, 1 - CISMeF





Preferred Label : Fibromatosis, gingival, 1;

Symbol : GINGF1;

CISMeF acronym : GGF1; GINGF; GINGF1; HGF;

Type : Phenotype, molecular basis known;

Alternative titles and symbols : GINGF; Fibromatosis, gingival, hereditary; HGF; GGF1;

Description : Gingival fibromatosis is a rare overgrowth condition characterized by a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of maxillary and mandibular keratinized gingiva (summary by Hart et al., 2002). - Genetic Heterogeneity of Hereditary Gingival Fibromatosis Other loci for gingival fibromatosis have been mapped to chromosome 5q (GINGF2; 605544), chromosome 2p23.3-p22.3 (GINGF3; 609955), and chromosome 11p15 (GINGF4; 611010). There is some evidence for a locus on chromosome 2p16-p13 (see MAPPING).;

Inheritance : Autosomal dominant;

Molecular basis : Caused by mutation in the SOS Ras/Rac guanine nucleotide exchange factor 1 gene (SOS1, 182530.0001);

Prefixed ID : #135300;

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03/05/2025


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