Preferred Label : Collagen, type II, alpha-1;
Symbol : COL2A1;
CISMeF acronym : COL2A1;
Type : Gene and phenotype, combined;
Alternative titles and symbols : Collagen, type II; Collagen of cartilage;
Included titles and symbols : Chondrocalcin; Vitreoretinopathy with phalangeal epiphyseal dysplasia;
Description : Collagens are major structural components of the extracellular matrix. Type II collagen,
also called cartilage collagen, is the major collagen synthesized by chondrocytes.
The same type of collagen occurs in the vitreous. Type II collagen is comprised of
3 alpha-1(II) chains. These are synthesized as larger procollagen chains, which contain
N- and C-terminal amino acid sequences called propeptides. After secretion into the
extracellular matrix, the propeptides are cleaved, forming the mature type II collagen
molecule (summary by Strom and Upholt, 1984 and Cheah et al., 1985).;
Prefixed ID : 120140;
Origin ID : 120140;
UMLS CUI : C1413580;
Automatic exact mappings (from CISMeF team)
- False automatic mappings
- NCIt concept(s)
- ORDO concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
