Preferred Label : α-effect;
IUPAC definition : A positive deviation of an α-nucleophile (a nucleophile bearing an unshared pair of
electrons on an atom adjacent to the nucleophilic site) from a Brønsted-type plot
of log k nuc vs. pKa constructed for a series of related normal nucleophiles. More
generally, it is the influence of the atom bearing a lone pair of electrons on the
reactivity at the adjacent site.;
Origin ID : A00006;
Automatic exact mappings (from CISMeF team)
- See also
A positive deviation of an α-nucleophile (a nucleophile bearing an unshared pair of
electrons on an atom adjacent to the nucleophilic site) from a Brønsted-type plot
of log k nuc vs. pKa constructed for a series of related normal nucleophiles. More
generally, it is the influence of the atom bearing a lone pair of electrons on the
reactivity at the adjacent site.
