ICD-11 definition : Palmoplantar pustulosis (PPP) is a chronic inflammatory skin condition characterized
by crops of sterile pustules on the palms and soles which erupt repeatedly over months
or years. The affected areas tend to become red and scaly; cracks may form and these
are often painful. It is strongly associated with smoking. It is associated with psoriasis
elsewhere on the body in up to 24% of patients though appears to have a genetic profile
distinct from psoriasis vulgaris. Interleukin-36 receptor gene polymorphisms are strongly
associated with generalized pustular psoriasis and have been detected in a minority
of patients with PPP.;
ICD-11 synonym : Palmoplantar pustular psoriasis; Pustular psoriasis of the palms and/or soles; PPP - [palmoplantar pustulosis]; Pustulosis palmaris et plantaris;
Palmoplantar pustulosis (PPP) is a chronic inflammatory skin condition characterized
by crops of sterile pustules on the palms and soles which erupt repeatedly over months
or years. The affected areas tend to become red and scaly; cracks may form and these
are often painful. It is strongly associated with smoking. It is associated with psoriasis
elsewhere on the body in up to 24% of patients though appears to have a genetic profile
distinct from psoriasis vulgaris. Interleukin-36 receptor gene polymorphisms are strongly
associated with generalized pustular psoriasis and have been detected in a minority
of patients with PPP.