Preferred Label : Periodontitis, aggressive, 1;
CISMeF acronym : JPD; JP; PPP;
Type : Phenotype, molecular basis known;
Alternative titles and symbols : JPD; PPP; Periodontitis, prepubertal; JP; Periodontitis, juvenile;
Description : Aggressive periodontitis, which may be generalized or localized, is characterized
by severe and protracted gingival infections, leading to tooth loss. Amounts of microbial
deposits are generally inconsistent with the severity of periodontal tissue destruction
and the progression of attachment and bone loss may be self arresting (American Academy
of Periodontology, 2000). The term 'aggressive periodontitis' replaced the terms 'early-onset,'
'prepubertal,' or 'juvenile periodontitis' at a 1999 International workshop for a
classification of periodontal disease and conditions, where it was decided that the
classification terminology should not be age dependent or require knowledge of rates
of progression (Armitage, 1999).;
Inheritance : Autosomal recessive;
Molecular basis : Caused by mutation in the cathepsin C gene (CTSC, 602365.0012);
Prefixed ID : #170650;
Origin ID : 170650;
UMLS CUI : C4551681;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- DO Cross reference
- False automatic mappings
- Genes related to phenotype
- HPO term(s)
- Not associated HPO term(s)
- See also inter- (CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to NTBT
