" /> Pituitary-dependent Cushing disease - CISMeF





ICD-11 code : 5A70.0;

Preferred Label : Pituitary-dependent Cushing disease;

ICD-11 definition : Pituitary-dependent Cushing disease is caused by a pituitary tumour, generally benign (adenoma) but rarely malignant (carcinoma), which secretes adrenocorticotropin (ACTH) autonomously, leading to hypercortisolism. The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery (TSS) remains the mainstay of treatment for this disease but requires considerable neurosurgical expertise and experience in order to optimize patient outcomes.;

ICD-11 synonym : Cushing syndrome or disease, pituitary-dependent; ACTH - [adrenocorticotropic hormone] secreting pituitary adenoma; Pituitary-dependent hyperadrenocorticism; pituitary acth hypersecretion; Corticotroph pituitary adenoma; ACTH secreting pituitary adenoma; Cushings basophilism; Overproduction of pituitary ACTH;

ICD-11 inclusion : pituitary-dependent hypercorticalism; Cushing's syndrome 3; Itsenko-Cushing syndrome; pituitary basophilism; Itsenko disease; suprarenogenic syndrome;

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Pituitary-dependent Cushing disease is caused by a pituitary tumour, generally benign (adenoma) but rarely malignant (carcinoma), which secretes adrenocorticotropin (ACTH) autonomously, leading to hypercortisolism. The condition is associated with increased morbidity and mortality that can be mitigated by treatments that result in sustained endocrine remission. Transsphenoidal pituitary surgery (TSS) remains the mainstay of treatment for this disease but requires considerable neurosurgical expertise and experience in order to optimize patient outcomes.

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11/12/2025


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