ICD-11 definition : A rare histological variant of glioblastoma (WHO grade IV) with a predominance of
bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network,
and a high frequency of TP53 mutations. (WHO);
ICD-11 inclusion : monstrocellular sarcoma of unspecified site; giant cell glioblastoma of unspecified site;
A rare histological variant of glioblastoma (WHO grade IV) with a predominance of
bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network,
and a high frequency of TP53 mutations. (WHO)