ICD-11 code : 8B60;
Preferred Label : Motor neuron disease;
ICD-11 definition : Motor neuron disease is a neurodegenerative disorder of undetermined etiology, characterized
by degeneration of upper motor neurons (cortical Betz cells and corticospinal tract)
or lower motor neurons (ventral horns of spinal cord and cranial nerve motor nuclei)
or both. Features of involvement of lower motor neurons (LMN) are atrophy, weakness,
fasciculations, hypotonia, decreased or absent deep tendon reflexes. Features of involvement
of upper motor neurons (UMN) are spasticity, exaggerated deep tendon reflexes, and
extensor plantar responses. Depending on the site of onset and the presence of UMN
or LMN features or both, MND has varying patterns and distributions of signs and symptoms.;
ICD-11 synonym : motor neurone disease; MND - [motor neurone disease];
ICD-11 acronym : MND;
ICD-11 inclusion : lateral paralysis; spinal progressive amyotrophy; creeping paralysis; Lou Gehrig disease; bulbar motor neuron disease; progressive spinal cord paralysis; lateral incomplete paralysis; bulbar paralysis; polioencephalitis; inferior; wasting paralysis; progressive paralysis; lateral complete paralysis; creeping palsy; hereditary motor neuron disease; progressive atrophic paralysis; lateral spine sclerosis; Duchenne-Aran atrophy; anterior horn cell disorder; wasting palsy; Duchenne-Aran muscle atrophy; bulbar palsy; progressive spinal paralysis; bulbar syndrome; chronic bulbar palsy; inferior poliencephalitis; supranuclear bulbar paralysis; anterior horn cell disease; lateral spinal sclerosis; chronic bulbar paralysis; cruveilhier; labioglossal paralysis;
ICD-11 "other" category code : 8B60.Y;
ICD-11 "unspecified" category code : 8B60.Z;
Origin ID : 661720689;
UMLS CUI : C0085084;
Automatic exact mappings (from CISMeF team)
Currated CISMeF NLP mapping
ICD-10 Mapping
Semantic type(s)
UMLS correspondences (same concept)
Motor neuron disease is a neurodegenerative disorder of undetermined etiology, characterized
by degeneration of upper motor neurons (cortical Betz cells and corticospinal tract)
or lower motor neurons (ventral horns of spinal cord and cranial nerve motor nuclei)
or both. Features of involvement of lower motor neurons (LMN) are atrophy, weakness,
fasciculations, hypotonia, decreased or absent deep tendon reflexes. Features of involvement
of upper motor neurons (UMN) are spasticity, exaggerated deep tendon reflexes, and
extensor plantar responses. Depending on the site of onset and the presence of UMN
or LMN features or both, MND has varying patterns and distributions of signs and symptoms.