Preferred Label : Polyinosinic-polycytidylic acid;
Definition : Polyinosinic:polycytidylic acid (usually abbreviated poly I:C or poly(I:C)) is an
immunostimulant. It is used in the form of its sodium salt to simulate viral infections.
Poly I:C is known to interact with toll-like receptor 3 (TLR3), which is expressed
at the endosomal membrane of B-cells, macrophages and dendritic cells. Poly I:C is
structurally similar to double-stranded RNA, which is present in some viruses and
is a natural stimulant of TLR3. Thus, Poly I:C can be considered a synthetic analog
of double-stranded RNA and is a common tool for scientific research on the immune
system. (Wikipédia);
Synonyme : Polyinosinic:polycytidylic acid; Poly I:C;
Origin ID : C20JKM3D-5;
Automatic exact mappings (from CISMeF team)
Polyinosinic:polycytidylic acid (usually abbreviated poly I:C or poly(I:C)) is an
immunostimulant. It is used in the form of its sodium salt to simulate viral infections.
Poly I:C is known to interact with toll-like receptor 3 (TLR3), which is expressed
at the endosomal membrane of B-cells, macrophages and dendritic cells. Poly I:C is
structurally similar to double-stranded RNA, which is present in some viruses and
is a natural stimulant of TLR3. Thus, Poly I:C can be considered a synthetic analog
of double-stranded RNA and is a common tool for scientific research on the immune
system. (Wikipédia)
