Veille documentaire MTPH

Médecine du travail du personnel hospitalier

A systematic review of human-to-human transmission of measles vaccine virus

Auteur     Kathryn P. Greenwood
Auteur     Radwan Hafiz
Auteur     Robert S. Ware
Auteur     Stephen B. Lambert
Volume     34
Numéro     23
Pages     2531-2536
Publication     Vaccine
ISSN     1873-2518
Date     May 17, 2016
Résumé     Measles is one of the most contagious human diseases. Administration of the live attenuated measles vaccine has substantially reduced childhood mortality and morbidity since its licensure in 1963. The live but attenuated form of the vaccine describes a virus poorly adapted to replicating in human tissue, but with a replication yield sufficient to elicit an immune response for long-term protection. Given the high transmissibility of the wild-type virus and that transmission of other live vaccine viruses has been documented, we conducted a systematic review to establish if there is any evidence of human-to-human transmission of the live attenuated measles vaccine virus. We reviewed 773 articles for genotypic confirmation of a vaccine virus transmitted from a recently vaccinated individual to a susceptible close contact. No evidence of human-to-human transmission of the measles vaccine virus has been reported amongst the thousands of clinical samples genotyped during outbreaks or endemic transmission and individual case studies worldwide.

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