A systematic review of human-to-human transmission of measles vaccine virus
Auteur Kathryn P. Greenwood
Auteur Radwan Hafiz
Auteur Robert S. Ware
Auteur Stephen B. Lambert
Volume 34
Numéro 23
Pages 2531-2536
Publication Vaccine
ISSN 1873-2518
Date May 17, 2016
Résumé Measles is one of the most contagious human diseases. Administration of the live attenuated measles vaccine has substantially reduced childhood mortality and morbidity since its licensure in 1963. The live but attenuated form of the vaccine describes a virus poorly adapted to replicating in human tissue, but with a replication yield sufficient to elicit an immune response for long-term protection. Given the high transmissibility of the wild-type virus and that transmission of other live vaccine viruses has been documented, we conducted a systematic review to establish if there is any evidence of human-to-human transmission of the live attenuated measles vaccine virus. We reviewed 773 articles for genotypic confirmation of a vaccine virus transmitted from a recently vaccinated individual to a susceptible close contact. No evidence of human-to-human transmission of the measles vaccine virus has been reported amongst the thousands of clinical samples genotyped during outbreaks or endemic transmission and individual case studies worldwide.
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doi:10.1016/j.vaccine.2016.03.092
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