Role of fomites in SARS transmission during the largest hospital outbreak in Hong Kong
Auteur Shenglan Xiao
Auteur Yuguo Li
Auteur Tze-Wai Wong
Auteur David S. C. Hui
Volume 12
Numéro 7
Pages e0181558
Publication PloS One
ISSN 1932-6203
Date 2017
Résumé The epidemic of severe acute respiratory syndrome (SARS) had a significant effect on global society in the early 2000s and the potential of its resurgence exists. Studies on the modes of transmission of SARS are limited though a number of outbreak studies have revealed the possible airborne route. To develop more specific and effective control strategies, we conducted a detailed mechanism-based investigation that explored the role of fomite transmission in the well-known Ward 8A outbreak. We considered three hypothetical transmission routes, i.e., the long-range airborne, fomite and combined routes, in 1,744 scenarios with combinations of some important parameters. A multi-agent model was used to predict the infection risk distributions of the three hypothetical routes. Model selection was carried out for different scenarios to compare the distributions of infection risk with that of the reported attack rates and select the hypotheses with the best fitness. Our results reveal that under the assumed conditions, the SARS coronavirus was most possible to have spread via the combined long-range airborne and fomite routes, and that the fomite route played a non-negligible role in the transmission.
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doi:10.1371/journal.pone.0181558
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