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Protective Effect of Contemporary Pertussis Vaccines: A Systematic Review and Meta-analysis

Auteur       T. Roice Fulton
Auteur       Varun K. Phadke
Auteur       Walter A. Orenstein
Auteur       Alan R. Hinman
Auteur       Wayne D. Johnson
Auteur       Saad B. Omer
Volume       62
Numéro       9
Pages       1100-1110
Publication       Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
ISSN       1537-6591
Date       May 01, 2016
Résumé       BACKGROUND: Acellular pertussis (aP) and whole-cell (wP) pertussis vaccines are presumed to have similar short-term (3 doses) of a primary series of a currently available aP or wP vaccine formulation. The primary outcome was based on the World Health Organization (WHO) clinical case definitions for pertussis. Study quality was assessed using the approach developed by the Child Health Epidemiology Research Group. We determined overall effect sizes using random-effects meta-analyses, stratified by vaccine (aP or wP) and study (efficacy or effectiveness) type. RESULTS: Meta-analysis of 2 aP vaccine efficacy studies (assessing the 3-component GlaxoSmithKline and 5-component Sanofi-Pasteur formulations) yielded an overall aP vaccine efficacy of 84% (95% confidence interval [CI], 81%-87%). Meta-analysis of 3 wP vaccine effectiveness studies (assessing the Behringwerke, Pasteur/Mérieux, and SmithKline Beecham formulations) yielded an overall wP vaccine effectiveness of 94% (95% CI, 88%-97%) (bothI(2)= 0%). CONCLUSIONS: Although all contemporary aP and wP formulations protect against pertussis disease, in this meta-analysis the point estimate for short-term protective effect against WHO-defined pertussis in young children was lower for currently available aP vaccines than wP vaccines.

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