Influenza vaccine effectiveness among healthcare workers in comparison to hospitalized patients: A 2004-2009 case-test, negative-control, prospective study

Publié le 12 janvier 2017 • Catégorie(s) : En accès libre, Vaccination • Mot(s) clef(s) : grippe

Auteur    P. Vanhems
Auteur    Y. Baghdadi
Auteur    S. Roche
Auteur    T. Bénet
Auteur    C. Regis
Auteur    B. Lina
Auteur    O. Robert
Auteur    N. Voirin
Auteur    R. Ecochard
Auteur    S. Amour
Volume    12
Numéro    2
Pages    485-490
Publication    Human Vaccines & Immunotherapeutics
ISSN    2164-554X
Date    2016
Résumé    The objective of this study was to calculate Vaccine Effectiveness (VE) in healthcare workers (HCW) and to compare VE between patients and HCW. A case-control investigation based on the prospective study was conducted between 2004 and 2009 in a teaching hospital. All HCW with influenza-like illness (ILI) from participating units (n = 24) were included, and vaccination status was characterized by interview. A total of 150 HCW presented ILI; 130 (87%) were female, 27 (18%) were positive for influenza, and 42 (28%) were vaccinated. Adjusted VE was 89% (95% CI 39 to 98). Among patients, adjusted VE was 42% (95% CI -39 to 76). The difference of VE (VEhcw – VEpat) was 46.15% (95% CI 2.41 to 144). The VE ratio (VEhcw / VEpat) was 2.09 (95% CI -1.60 to 134.17). Influenza VE differed between HCW and patients when the flu season was taken into account. This finding confirms the major impact of host determinants on influenza VE.