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Médecine du travail du personnel hospitalier

Guillain-Barré syndrome following the 2009 pandemic monovalent and seasonal trivalent influenza vaccination campaigns in Spain from 2009 to 2011: outcomes from active surveillance by a neurologist network, and records from a country-wide hospital discharge database

Auteur        Enrique Alcalde-Cabero
Auteur        Javier Almazán-Isla
Auteur        Fernando J. García López
Auteur        José Ramón Ara-Callizo
Auteur        Fuencisla Avellanal
Auteur        Carlos Casasnovas
Auteur        Carlos Cemillán
Auteur        José Ignacio Cuadrado
Auteur        Jacinto Duarte
Auteur        María Dolores Fernández-Pérez
Auteur        Óscar Fernández
Auteur        Juan Antonio García Merino
Auteur        Rosa García Montero
Auteur        Dolores Montero
Auteur        Julio Pardo
Auteur        Francisco Javier Rodríguez-Rivera
Auteur        María Ruiz-Tovar
Auteur        Jesús de Pedro-Cuesta
Auteur        Spanish GBS Epidemiology Study Group
Volume        16
Pages        75
Publication        BMC neurology
ISSN        1471-2377
Date        May 21, 2016
Résumé        BACKGROUND: Studies have shown a slight excess risk in Guillain-Barré syndrome (GBS) incidence associated with A(H1N1)pdm09 vaccination campaign and seasonal trivalent influenza vaccine immunisations in 2009-2010. We aimed to assess the incidence of GBS as a potential adverse effect of A(H1N1)pdm09 vaccination. METHODS: A neurologist-led network, active at the neurology departments of ten general hospitals serving an adult population of 4.68 million, conducted GBS surveillance in Spain in 2009-2011. The network, established in 1996, carried out a retrospective and a prospective study to estimate monthly alarm thresholds in GBS incidence and tested them in 1998-1999 in a pilot study. Such incidence thresholds additionally to observation of GBS cases with immunisation antecedent in the 42 days prior to clinical onset were taken as alarm signals for 2009-2011, since November 2009 onwards. For purpose of surveillance, in 2009 we updated both the available centres and the populations served by the network. We also did a retrospective countrywide review of hospital-discharged patients having ICD-9-CM code 357.0 (acute infective polyneuritis) as their principal diagnosis from January 2009 to December 2011. RESULTS: Among 141 confirmed of 148 notified cases of GBS or Miller-Fisher syndrome, Brighton 1-2 criteria in 96 %, not a single patient was identified with clinical onset during the 42-day time interval following A(H1N1)pdm09 vaccination. In contrast, seven cases were seen during a similar period after seasonal campaigns. Monthly incidence figures did not, however, exceed the upper 95 % CI limit of expected incidence. A retrospective countrywide review of the registry of hospital-discharged patients having ICD-9-CM code 357.0 (acute infective polyneuritis) as their principal diagnosis did not suggest higher admission rates in critical months across the period December 2009-February 2010. CONCLUSIONS: Despite limited power and underlying reporting bias in 2010-2011, an increase in GBS incidence over background GBS, associated with A(H1N1)pdm09 monovalent or trivalent influenza immunisations, appears unlikely.

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