Interferon-γ release assay vs. tuberculin skin test for tuberculosis screening in exposed healthcare workers: a longitudinal multicenter comparative study
Auteur Jean-Christophe Lucet
Auteur Dominique Abiteboul
Auteur Candice Estellat
Auteur Carine Roy
Auteur Sylvie Chollet-Martin
Auteur Florence Tubach
Auteur Guislaine Carcelain
Auteur QUANTIPS Study Group
Volume 36
Numéro 5
Pages 569-574
Publication Infection Control and Hospital Epidemiology
ISSN 1559-6834
Date May 2015
Résumé OBJECTIVE: Healthcare workers (HCWs), especially those caring for patients with tuberculosis (TB), are at high risk of acquiring that disease. The poor specificity of tuberculin skin testing (TST) prompted us to evaluate the effectiveness of the interferon-γ release assay (IGRA) in comparison with TST in a large prospective, multicenter, 1-year study of HCWs with occupational exposure to TB. METHODS: HCWs from high-risk units at 14 university hospitals were invited to participate and underwent both TST and IGRA (first Quantiferon TB Gold-IT®, QFT-G, then T-SPOT.TB® if QFT-G was indeterminate) at baseline and after 1 year. We collected demographic characteristics, country of birth, history of TB, immunosuppression, past exposure to TB, history of BCG vaccination, results of most recent TST, job category, and duration of current function. RESULTS: Among 807 HCWs enrolled, current or past TST at baseline was positive (≥15 mm) in 282 (34.9%); the IGRA was positive in 113 (14.0%) and indeterminate in 3 (0.4%). After 1 year, 594 HCWs had both an IGRA and TST (or prior TST≥15 mm) at baseline and an IGRA and TST (if indicated). The conversion rate was 2.5% (9 of 367) with TST and 7.6% (45 of 594) with IGRA, with poor agreement between the 2 tests. Using only QFT-G, conversion (9.9%) and reversion (17.8%) rates were higher for baseline QFT-G positive quantitative values
Chercher cette référence sur : Google Scholar, Worldcat
doi:10.1017/ice.2015.19
Laisser une réponse
Vous devez etre connectez Pour poster un commentaire