Veille documentaire MTPH

Auteur       Lakshmi Sukumaran
Auteur       Natalie L. McCarthy
Auteur       Elyse O. Kharbanda
Auteur       Eric S. Weintraub
Auteur       Gabriela Vazquez-Benitez
Auteur       Michael M. McNeil
Auteur       Rongxia Li
Auteur       Nicola P. Klein
Auteur       Simon J. Hambidge
Auteur       Allison L. Naleway
Auteur       Marlene M. Lugg
Auteur       Michael L. Jackson
Auteur       Jennifer P. King
Auteur       Frank DeStefano
Auteur       Saad B. Omer
Auteur       Walter A. Orenstein
Volume       126
Numéro       5
Pages       1069-1074
Publication       Obstetrics and Gynecology
ISSN       1873-233X
Date       Nov 2015
Résumé       OBJECTIVE: To evaluate the safety of coadministering tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) and influenza vaccines during pregnancy by comparing adverse events after concomitant and sequential vaccination. METHODS: We conducted a retrospective cohort study of pregnant women aged 14-49 years in the Vaccine Safety Datalink from January 1, 2007, to November 15, 2013. We compared medically attended acute events (fever, any acute reaction) and adverse birth outcomes (preterm delivery, low birth weight, small for gestational age) in women receiving concomitant Tdap and influenza vaccination and women receiving sequential vaccination. RESULTS: Among 36,844 pregnancies in which Tdap and influenza vaccines were administered, the vaccines were administered concomitantly in 8,464 (23%) pregnancies and sequentially in 28,380 (77%) pregnancies. Acute adverse events after vaccination were rare. We found no statistically significant increased risk of fever or any medically attended acute adverse event in pregnant women vaccinated concomitantly compared with sequentially. When analyzing women at 20 weeks of gestation or greater during periods of influenza vaccine administration, there were no differences in preterm delivery, low-birth-weight, or small-for-gestational-age neonates between women vaccinated concomitantly compared with sequentially in pregnancy. CONCLUSION: Concomitant administration of Tdap and influenza vaccines during pregnancy was not associated with a higher risk of medically attended adverse acute outcomes or birth outcomes compared with sequential vaccination. LEVEL OF EVIDENCE: II.