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Immune memory response induced in vitro by recombinant hepatitis B surface antigen challenge 13-18 years after primary vaccination

Auteur     Andréa do Livramento
Auteur     Júnia Schultz
Auteur     Keila Zaniboni Siqueira Batista
Auteur     Arício Treitinger
Auteur     Caio Maurício Mendes de Cordova
Auteur     Celso Spada
Volume     86
Numéro     10
Pages     1700-1704
Publication     Journal of Medical Virology
ISSN     1096-9071
Date     Oct 2014
Résumé     The question of whether booster doses are required to maintain long-term protection against hepatitis B virus (HBV) after primary vaccination remains to be determined. Thus, the aim of this study was to evaluate the immune memory responses to hepatitis B surface antigen (HBsAg) challenge in vaccinated individuals through an in vitro-specific stimulation assay. Peripheral blood mononuclear cells (4 × 10(6)  cells/ml) were stimulated with 50 ng/ml of recombinant HBsAg. In vitro anamnestic antibody responses, as shown by detection of high avidity antibody in culture supernatants, were found 13-18 years after primary vaccination and were not correlated with serum antibodies (r = -0.177; P = 0.377). In addition, the findings from this study indicate that immune memory against hepatitis B was well preserved in 40.0% and 60.0% of vaccinees with anti-HBs levels less than 10 IU/L or lacking serum antibodies altogether, respectively. In conclusion, the data suggest the presence of immunological memory in vaccinated individuals, including those who showed anti-HBs <10 IU/L or undetectable antibody.

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