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Médecine du travail du personnel hospitalier

Cumulative lead exposure and age at menopause in the Nurses’ Health Study cohort

Auteur     Ki-Do Eum
Auteur     Marc G. Weisskopf
Auteur     Linda H. Nie
Auteur     Howard Hu
Auteur     Susan A. Korrick
Volume     122
Numéro     3
Pages     229-234
Publication     Environmental Health Perspectives
ISSN     1552-9924
Date     Mar 2014
Résumé     BACKGROUND: Early menopause has been associated with many adverse health outcomes, including increased risk of cardiovascular disease morbidity and mortality. Lead has been found to be adversely associated with female reproductive function, but whether exposures experienced by the general population are associated with altered age at menopause has not been explored. OBJECTIVE: Our goal was to assess the association between cumulative lead exposure and age at natural menopause. METHODS: Self-reported menopausal status and bone lead concentration measured with K-shell X-ray fluorescence-a biomarker of cumulative lead exposure-were obtained from 434 women participants in the Nurses’ Health Study. RESULTS: The mean (± SD) age at natural menopause was 50.8 ± 3.6 years. Higher tibia lead level was associated with younger age at menopause. In adjusted analyses, the average age of menopause for women in the highest tertile of tibia lead was 1.21 years younger (95% CI: -2.08, -0.35) than for women in the lowest tertile (p-trend = 0.006). Although the number of cases was small (n = 23), the odds ratio for early menopause (< 45 years of age) was 5.30 (95% CI: 1.42, 19.78) for women in the highest tertile of tibia lead compared with those in the lowest tertile (p-trend = 0.006). There was no association between patella or blood lead and age at menopause. CONCLUSIONS: Our results support an association between low-level cumulative lead exposure and an earlier age at menopause. These data suggest that low-level lead exposure may contribute to menopause-related health outcomes in older women through effects on age at menopause.

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