Veille documentaire MTPH

Médecine du travail du personnel hospitalier

Biological exposure metrics of beryllium-exposed dental technicians

Auteur Moshe Stark
Auteur Yehuda Lerman
Auteur Arik Kapel
Auteur Asher Pardo
Auteur Yehuda Schwarz
Auteur Lee Newman
Auteur Lisa Maier
Auteur Elizabeth Fireman
Volume 69
Numéro 2
Pages 89-99
Publication Archives of environmental & occupational health
Date 2014
Résumé Beryllium is commonly used in the dental industry. This study investigates the association between particle size and shape in induced sputum (IS) with beryllium exposure and oxidative stress in 83 dental technicians. Particle size and shape were defined by laser and video, whereas beryllium exposure data came from self-reports and beryllium lymphocyte proliferation test (BeLPT) results. Heme oxygenase-1 (HO1) gene expression in IS was evaluated by quantitative polymerase chain reaction. A high content of particles (92%) in IS >5 μ in size is correlated to a positive BeLPT risk (odds ratio [OR] = 3.4, 95% confidence interval [CI]: 0.9-13). Use of masks, hoods, and type of exposure yielded differences in the transparency of IS particles (gray level) and modulate HO1 levels. These results indicate that parameters of size and shape of particles in IS are sensitive to workplace hygiene, affect the level of oxidative stress, and may be potential markers for monitoring hazardous dust exposures.

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