Veille documentaire MTPH

Médecine du travail du personnel hospitalier

Night work and breast cancer: A population-based case-control study in France (the CECILE study)

Auteur     Florence Menegaux
Auteur     Thérèse Truong
Auteur     Antoinette Anger
Auteur     Emilie Cordina-Duverger
Auteur     Farida Lamkarkach
Auteur     Patrick Arveux
Auteur     Pierre Kerbrat
Auteur     Joëlle Févotte
Auteur     Pascal Guénel
Résumé     Night work involving disruption of circadian rhythm was suggested as a possible cause of breast cancer. We examined the role of night work in a large population-based case-control study carried out in France between 2005 and 2008. Lifetime occupational history including work schedules of each night work period was elicited in 1232 cases of breast cancer and 1317 population controls. Thirteen percent of the cases and eleven percent of the controls had ever worked on night shifts (OR = 1.27 [95% confidence interval = 0.99-1.64]). Odds ratios were 1.35 [1.01-1.80] in women who worked on overnight shifts, 1.40 [1.01-1.92] in women who had worked at night for 4.5 or more years, and 1.43 [1.01-2.03] in those who worked less than 3 nights per week on average. The odds ratio was 1.95 [1.13-3.35] in women employed in night work for more than 4 years before their first full-term pregnancy, a period where mammary gland cells are incompletely differentiated and possibly more susceptible to circadian disruption effects. Our results support the hypothesis that night work plays a role in breast cancer, particularly in women who started working at night before first full-term pregnancy.
Publication     International journal of cancer. Journal international du cancer
Date     Jun 12, 2012

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