Night work and breast cancer: A population-based case-control study in France (the CECILE study)
Auteur Florence Menegaux
Auteur Thérèse Truong
Auteur Antoinette Anger
Auteur Emilie Cordina-Duverger
Auteur Farida Lamkarkach
Auteur Patrick Arveux
Auteur Pierre Kerbrat
Auteur Joëlle Févotte
Auteur Pascal Guénel
Résumé Night work involving disruption of circadian rhythm was suggested as a possible cause of breast cancer. We examined the role of night work in a large population-based case-control study carried out in France between 2005 and 2008. Lifetime occupational history including work schedules of each night work period was elicited in 1232 cases of breast cancer and 1317 population controls. Thirteen percent of the cases and eleven percent of the controls had ever worked on night shifts (OR = 1.27 [95% confidence interval = 0.99-1.64]). Odds ratios were 1.35 [1.01-1.80] in women who worked on overnight shifts, 1.40 [1.01-1.92] in women who had worked at night for 4.5 or more years, and 1.43 [1.01-2.03] in those who worked less than 3 nights per week on average. The odds ratio was 1.95 [1.13-3.35] in women employed in night work for more than 4 years before their first full-term pregnancy, a period where mammary gland cells are incompletely differentiated and possibly more susceptible to circadian disruption effects. Our results support the hypothesis that night work plays a role in breast cancer, particularly in women who started working at night before first full-term pregnancy.
Publication International journal of cancer. Journal international du cancer
Date Jun 12, 2012
Chercher cette référence sur : Google Scholar, Worldcat
doi:10.1002/ijc.27669
Laisser une réponse
Vous devez etre connectez Pour poster un commentaire