Serogroup B meningococcal vaccines-an unfinished story
Auteur Manish Sadarangani
Auteur Andrew J Pollard
Résumé Most invasive meningococcal disease in developed countries is caused by Neisseria meningitidis with a serogroup B capsule. However, despite availability of vaccines for other serogroups since the 1960s, no serogroup B vaccine exists. In this Review we look at the development of serogroup B vaccines over the past 40 years. Outer membrane vesicle vaccines have been successfully used to control geographically isolated epidemics, but most have not been highly immunogenic in young children or provided broad cross-protection from infections with other strains. Vaccines based on subcapsular antigens have recently produced promising results in early clinical trials, and the disease burden might be substantially reduced over the next few years.
Publication The Lancet Infectious Diseases
Volume 10
Numéro 2
Pages 112-124
Date Feb 2010
Chercher cette référence sur : Google Scholar, Worldcat
doi:10.1016/S1473-3099(09)70324-X
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