Persistence of antibodies and immune memory to hepatitis B vaccine 20 years after infant vaccination in Thailand
Auteur Yong Poovorawan
Auteur Voranush Chongsrisawat
Auteur Apiradee Theamboonlers
Auteur Hans L Bock
Auteur Maarten Leyssen
Auteur Jeanne-Marie Jacquet
Résumé Booster vaccination against hepatitis B (HBV) is not currently recommended, although debate continues on the duration of protection after priming. We assessed antibody persistence and immune memory to hepatitis B 20 years after priming with a recombinant HBV-vaccine during infancy. Infants were vaccinated at birth, 1, 2 and 12 months of age. A subset received a booster dose at Year 5. Antibody persistence was measured approximately yearly until Year 20. Immune memory was assessed by administration of HBV booster dose. At Year 20, anti-HBs seroprotection rates and GMCs tended to be higher in Year 5 boosted than unboosted recipients (83.9% versus 60.5%). After the Year 20 booster dose, anti-HBs anamnestic responses were within the same range 95.8% of subjects in both groups. Primary and booster vaccination with HBV-vaccine in infants induces sustained seroprotection and immune memory against hepatitis B for up to 20 years. Higher persisting seroprotection rates in subjects boosted at Year 5 did not translate into apparent differences in immune memory in a high endemic country.
Publication Vaccine
Volume 28
Numéro 3
Pages 730-736
Date Jan 8, 2010
Chercher cette référence sur : Google Scholar, Worldcat
doi:10.1016/j.vaccine.2009.10.074
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