Veille documentaire MTPH

Médecine du travail du personnel hospitalier

Persistence of antibodies and immune memory to hepatitis B vaccine 20 years after infant vaccination in Thailand

Auteur     Yong Poovorawan
Auteur     Voranush Chongsrisawat
Auteur     Apiradee Theamboonlers
Auteur     Hans L Bock
Auteur     Maarten Leyssen
Auteur     Jeanne-Marie Jacquet
Résumé     Booster vaccination against hepatitis B (HBV) is not currently recommended, although debate continues on the duration of protection after priming. We assessed antibody persistence and immune memory to hepatitis B 20 years after priming with a recombinant HBV-vaccine during infancy. Infants were vaccinated at birth, 1, 2 and 12 months of age. A subset received a booster dose at Year 5. Antibody persistence was measured approximately yearly until Year 20. Immune memory was assessed by administration of HBV booster dose. At Year 20, anti-HBs seroprotection rates and GMCs tended to be higher in Year 5 boosted than unboosted recipients (83.9% versus 60.5%). After the Year 20 booster dose, anti-HBs anamnestic responses were within the same range 95.8% of subjects in both groups. Primary and booster vaccination with HBV-vaccine in infants induces sustained seroprotection and immune memory against hepatitis B for up to 20 years. Higher persisting seroprotection rates in subjects boosted at Year 5 did not translate into apparent differences in immune memory in a high endemic country.
Publication     Vaccine
Volume     28
Numéro     3
Pages     730-736
Date     Jan 8, 2010

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