Bordetella pertussis and pertussis vaccines
Auteur Nicole Guiso
Résumé Bordetella pertussis is a human-specific pathogen that causes whooping cough. The use of pertussis whole-cell vaccines in infants and toddlers led to decreased circulation of the bacterium in the child population and a marked decrease in the incidence of the disease. However, vaccine does not result in life-long immunity; indeed, the circulation of the bacterium has not been controlled in the adult population. Universal adult booster immunization is now possible using pertussis acellular vaccines, which target-and are thus likely to control-the virulence of this bacterium.
Publication Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Volume 49
Numéro 10
Pages 1565-1569
Date Nov 15, 2009
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doi:10.1086/644733
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