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Low Sensitivity of a Whole-Blood Interferon-? Release Assay for Detection of Active Tuberculosis

Clinical Infectious Diseases, 2007;44:69-73
Low Sensitivity of a Whole-Blood Interferon-? Release Assay for Detection of Active Tuberculosis
Puneet K. Dewan, Jennifer Grinsdale, and L. Masae Kawamura
The sensitivity of an interferon- assay (Quantiferon-TB Gold; Cellestis) was evaluated for the detection of tuberculosis among 242 persons with suspected tuberculosis in San Francisco, California. Thirty-seven subjects had culture-confirmed tuberculosis. Excluding 1 indeterminate result, 23 (64%; 95% confidence interval, 48%–78%) of 36 subjects had positive results using the QuantiFERON-TB Gold assay. The 64% sensitivity suggests that the QuantiFERON-TB Gold assay should not be used alone to exclude active tuberculosis.

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