AimTo analyze if subretinal fluid (SRF) Endothelin-1 (ET-1) – a vasoconstrictor, mitogenic and pro-apoptotic peptide – levels are related to VA in rhegmatogenous retinal detachment (RD) cases with macula “off”.Materials and MethodsSixty six healthy patients between 42 and 70 years with unilateral RD candidates for scleral buckling surgery (PVRResultsMean IR-ET-1 values were: plasma, 2.91pg/ml with Sd0.44 and SRF, 10.71 pg/ml with Sd 7.95. Mean VA values were: VA pre-, 0.31 with Sd 0.16; VA post, 0.66 with Sd 0.29 and VA improvement, 0.35 with Sd 0.18. Plasma IR-ET-1 showed significant (p<0.0001) negative linear correlations with VA pre- (r=0.518), VA post- (r=0.698) and VA improvement (r=0.648). SRF- IR-ET-1 showed significant (p<0.0001) negative linear correlations with VA pre- (r=0.48), VA post (r=0.61) and VA improvement (r=0.54).DiscussionWhen we study the correlation between SRF - plasma IR-ET-1, this correlation is negative and higher for VA post-. Previously we had demonstrated the increased levels of IR-ET-1 in the vitreous related with proliferative complications of RD.ConclusionCorrelations between IR-ET-1 and VA were negative and higher for VA post-. This finding supports the idea of doing primary vitrectomy and may be a coadjutant pharmacologic therapy in these cases.