A combination of 50 mcg of ethinyl estradiol (EE) and 2 mg cyproterone acetate was prescribed for 50 women seeking oral contraceptives who showed signs of hyperandrogenism. The women averaged 25 years of age and the treatments lasted an average of 12 months. Very satisfactory results were seen in 32 of the 43 cases of acne within 4 cycles, and in 6 other cases the results were slower. Results depended on the severity of the acne. Satisfactory results were obtained in 22 of 27 cases of seborrhea, usually within the 1st 4 cycles. Results with hirsutism were satisfactory in 9 of 11 cases but the improvement was slow and often incomplete due to the weak dosage of cyproterone acetate. In all 3 cases of alopecia the results were satisfactory but the improvement came slowly. Most patients reported more regular periods, 8 reported spotting, 11 reported enlargement of breasts with heaviness and sensitivity, none reported effects on the libido, 8 reported nausea which disappeared rapidly, 10 reported headaches, 7 reported heaviness of legs, 5 reported gaining 2 kilos or more but 6 reported losing, and 8 reported mood problems. The only biological change noted in the sample was elevation in triglycerides in 5 women and transitory fluctuations in 7 others. The combination of EE and cyproterone acetate appears to be an excellent choice for young women with signs of hyperandrogenism.