Preferred Label : Beta-Glucan;
NCIt definition : A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with
immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan
binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the
receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds
to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of
circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the
same way as they kill iC3b-coated yeast. (NCI04);
Alternative definition : NCI-GLOSS: A substance found in bacteria, plants, and certain foods, such as baker's
yeast, cereal grains, and mushrooms. It is a type of polysaccharide that is made of
a string of glucose (sugar) molecules joined together. Beta-glucan may stimulate the
immune system and help kill cancer cells. It is being studied in the treatment of
cancer. It is a type of biological response modifier.;
ChEBI ID : CHEBI:28793;
Codes from synonyms : CDR0000044147;
Origin ID : C2678;
UMLS CUI : C1134651;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
