axin signaling complex

Preferred Label : axin signaling complex;

MeSH definition : A specific complex of WNT SIGNALING PATHWAY proteins that mediates the phosphorylation-dependent destruction of cytosolic BETA-CATENIN. The complex is disrupted by cell surface binding of WNT PROTEINS, which allows beta-catenin levels to rise to the point where they migrate to the CELL NUCLEUS and activate transcription.;

MeSH synonym : signaling complex, axin; axin signaling complex proteins; beta-Catenin destruction complex; destruction complex, beta-Catenin; beta catenin destruction complex;

Details

Origin ID

D060465;

UMLS CUI

C1325595;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
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- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- beta-catenin destruction complex [GO term]
Record concept(s)
- axin signaling complex [MeSH concept]
Semantic type(s)
- Cell Component [UMLS semantic type]
UMLS correspondences (same concept)
- beta-catenin destruction complex [GO term]

Keyword's position in hierarchy(ies) :

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