Preferred Label : cyclic nucleotide phosphodiesterases, type 2;
MeSH definition : A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of
CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of
this subtype can be produced due to multiple alternative mRNA splicing. The subfamily
is expressed in a broad variety of tissues and may play a role in mediating cross-talk
between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified
as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional
specificity for CYCLIC GMP.;
MeSH synonym : cyclic gmp-stimulated phosphodiesterase; phosphodiesterase, cyclic gmp-stimulated; pde2 phosphodiesterases; pde2 phosphodiesterase; cyclic gmp stimulated phosphodiesterase; cyclic nucleotide phosphodiesterase pde2 family;
MeSH hyponym : cyclic nucleotide phosphodiesterases, type 2A; cGMP-Dependent 3',5'-Cyclic Phosphodiesterase; 3',5'-Cyclic Phosphodiesterase, cGMP-Dependent; cGMP Dependent 3',5' Cyclic Phosphodiesterase; Phosphodiesterase 2A;
MeSH Related Number : cyclic nucleotide phosphodiesterases, type 2A; EC 3.1.4.17;
Registry Number MeSH : EC 3.1.4.17;
Related CAS MeSH : EC 3.1.4.17 (Cyclic nucleotide phosphodiesterases, type 2A);
Is substance : O;
UNII : EC 3.1.4.17;
Origin ID : D054678;
UMLS CUI : C0960334;
Allowable qualifiers
- Record concept(s)
- Related MeSH Supplementary Concept(s)
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A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of
CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of
this subtype can be produced due to multiple alternative mRNA splicing. The subfamily
is expressed in a broad variety of tissues and may play a role in mediating cross-talk
between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified
as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional
specificity for CYCLIC GMP.
