MeSH definition : Multimeric protein complexes formed in the CYTOSOL that play a role in the activation
of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and
release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING
FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis
by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.;
MeSH synonym : complex, apoptosomal protein; Apoptosome; apoptosomal protein complex; protein complex, apoptosomal;
Wikipedia link : https://en.wikipedia.org/wiki/Apoptosome;
Multimeric protein complexes formed in the CYTOSOL that play a role in the activation
of APOPTOSIS. They can occur when MITOCHONDRIA become damaged due to cell stress and
release CYTOCHROME C. Cytosolic cytochrome C associates with APOPTOTIC PROTEASE-ACTIVATING
FACTOR 1 to form the apoptosomal protein complex. The apoptosome signals apoptosis
by binding to and activating specific INITIATOR CASPASES such as CASPASE 9.