squalene monooxygenase

Preferred Label : squalene monooxygenase;

MeSH definition : The second enzyme in the committed pathway for CHOLESTEROL biosynthesis, this enzyme catalyzes the first oxygenation step in the biosynthesis of STEROLS and is thought to be a rate limiting enzyme in this pathway. Specifically, this enzyme catalyzes the conversion of SQUALENE to (S)-squalene-2,3-epoxide.;

MeSH synonym : squalene epoxidase; monooxygenase, squalene; squalene monooxygenase (2,3-epoxidizing); epoxidase, squalene;

MeSH Related Number : 9029-62-3 (CRN);

Registry Number MeSH : EC 1.14.99.7; EC 1.14.13.132; EC 1.14.14.17;

Wikipedia link : https://en.wikipedia.org/wiki/Squalene monooxygenase;

Is substance : O;

UNII : EC 1.14.14.17;

Details

Origin ID

D050603;

UMLS CUI

C0075086;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Squalene epoxidase [OMIM gene]
- squalene epoxidase [HGNC gene]
Record concept(s)
- squalene monooxygenase [MeSH concept]
Related MeSH Supplementary Concept(s)
- SQLE protein, human [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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