Preferred Label : leukocyte rolling;
MeSH definition : Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature.
The tethering and rolling involves interaction with SELECTINS and other adhesion molecules
in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated
by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation
for transmigration through the interendothelial cell junction. (From Abbas, Cellular
and Molecular Immunology, 3rd ed);
MeSH synonym : rolling, leucocyte; rolling, leukocyte; leucocyte rolling;
Origin ID : D036904;
UMLS CUI : C1136143;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
Movement of tethered, spherical LEUKOCYTES along the endothelial surface of the microvasculature.
The tethering and rolling involves interaction with SELECTINS and other adhesion molecules
in both the ENDOTHELIUM and leukocyte. The rolling leukocyte then becomes activated
by CHEMOKINES, flattens out, and firmly adheres to the endothelial surface in preparation
for transmigration through the interendothelial cell junction. (From Abbas, Cellular
and Molecular Immunology, 3rd ed)
