Preferred Label : mice, inbred mrl lpr;
MeSH definition : A mouse substrain that is genetically predisposed to the development of systemic lupus
erythematosus-like syndrome, which has been found to be clinically similar to the
human disease. It has been determined that this mouse strain carries a mutation in
the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive
deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.;
MeSH synonym : mice, mrl lpr; mrl lpr mice; mrl lpr mouse; mouse, mrl lpr; mouse, inbred mrl lpr;
CISMeF synonym : lpr mice, mrl; lpr mouse, mrl;
MeSH annotation : a strain predisposed to develop of systemic lupus erythematosus; MRL stands for Murphy-Roths
Lymphoma, lpr stands for LymphoPRoliferative; NIM when exper animal: no qualif; when
IM, qualif permitted; do not forget also to check MICE; in titles & translations use
lpr (the letter l), not 1pr (the figure one); NIM with no qualifiers when experimental animal;
Origin ID : D019463;
UMLS CUI : C0376632;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
A mouse substrain that is genetically predisposed to the development of systemic lupus
erythematosus-like syndrome, which has been found to be clinically similar to the
human disease. It has been determined that this mouse strain carries a mutation in
the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive
deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
