Preferred Label : receptors, polymeric immunoglobulin;
MeSH definition : Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate
transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions.
They are found on the surfaces of epithelial cells and hepatocytes. After binding
to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport
by vesicle, and secretion into the lumen by exocytosis. Before release, the part of
the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically
cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology,
1989);
MeSH synonym : immunoglobulin receptors, polymeric; poly ig receptor; poly-ig receptor; polymeric immunoglobulin receptor; polymeric immunoglobulin receptors; receptor, polyimmunoglobulin; receptor, polymeric ig; receptor, polymeric immunoglobulin; receptor, poly-ig; polyimmunoglobulin receptor; immunoglobulin receptor, polymeric; polymeric ig receptor; ig receptor, polymeric;
MeSH annotation : specialized Fc receptors; DF: RECEPT POLY IG;
Is substance : O;
Origin ID : D019056;
UMLS CUI : C0071613;
Allowable qualifiers
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
Specialized Fc receptors (RECEPTORS, FC) for polymeric immunoglobulins, which mediate
transcytosis of polymeric IMMUNOGLOBULIN A and IMMUNOGLOBULIN M into external secretions.
They are found on the surfaces of epithelial cells and hepatocytes. After binding
to IMMUNOGLOBULIN A, the receptor-ligand complex undergoes endocytosis, transport
by vesicle, and secretion into the lumen by exocytosis. Before release, the part of
the receptor (SECRETORY COMPONENT) that is bound to IMMUNOGLOBULIN A is proteolytically
cleaved from its transmembrane tail. (From Rosen et al., The Dictionary of Immunology,
1989)
