Preferred Label : substrate cycling;
MeSH definition : A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act
simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results
of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product
conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis
and glycolysis pathways and cycling of the triglycerides and fatty acid pathways.
Rates of substrate cycling may be increased many-fold in association with hypermetabolic
states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.;
MeSH synonym : cycling, substrate; cyclings, substrate; substrate cyclings;
MeSH hyponym : futile cycles; Cycle, Futile; Cycles, Futile; Futile Cycle; Futile Substrate Cycles; Cycle, Futile Substrate; Cycles, Futile Substrate; Futile Substrate Cycle; Substrate Cycle, Futile; Substrate Cycles, Futile; Futile Cycling; Cycling, Futile; Cyclings, Futile; Futile Cyclings; Futile Substrate Cycling; Cycling, Futile Substrate; Cyclings, Futile Substrate; Futile Substrate Cyclings; Substrate Cycling, Futile; Substrate Cyclings, Futile;
MeSH annotation : restricted to enzyme activity; almost never IM; coord NIM with specific enzyme (IM);
Wikipedia link : https://en.wikipedia.org/wiki/Substrate cycling;
Origin ID : D015219;
UMLS CUI : C0038591;
Allowable qualifiers
- Record concept(s)
- Semantic type(s)
A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act
simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results
of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product
conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis
and glycolysis pathways and cycling of the triglycerides and fatty acid pathways.
Rates of substrate cycling may be increased many-fold in association with hypermetabolic
states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.
