2-isopropylmalate synthase

Preferred Label : 2-isopropylmalate synthase;

MeSH definition : An enzyme that catalyzes the first step in the biosynthetic pathway to LEUCINE, forming isopropyl malate from acetyl-CoA and alpha-ketoisovaleric acid. This enzyme was formerly listed as EC 4.1.3.12.;

MeSH synonym : synthase, alpha-isopropylmalate; synthase, 2-isopropylmalate; alpha-isopropylmalate synthase; alpha isopropylmalate synthase; 2 isopropylmalate synthase;

MeSH CAS label : 3-Carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating);

MeSH Related Number : 9030-98-2 (CAS RN);

Registry Number MeSH : EC 2.3.3.13;

Is substance : O;

UNII : EC 2.3.3.13;

Details

Origin ID

D015079;

UMLS CUI

C0000291;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- 2-isopropylmalate synthase [SNOMED Notion]
- 2-isopropylmalate synthase (substance) [SNOMED CT concept]
Record concept(s)
- 2-Isopropylmalate synthase [MeSH concept]
Related MeSH Supplementary Concept(s)
- LEU4 protein, S cerevisiae [MeSH Supplementary Concept]
- LEU9 protein, S cerevisiae [MeSH Supplementary Concept]
- MAM3 protein, arabidopsis [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- 2-isopropylmalate synthase [SNOMED Notion]
- 2-isopropylmalate synthase (substance) [SNOMED CT concept]

Keyword's position in hierarchy(ies) :

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